The Connection Between MS And Aspartame
By Russell L. Blaylock, MD
Recently, much controversy has surrounded a claim that aspartame may produce an MS-like syndrome. A current review of recent peer-reviewed scientific studies have disclosed a pathophysiological mechanism to explain this connection. As far back as 1996 it was shown that the lesions produced in the myelin sheath of axons in cases of multiple sclerosis were related to excitatory receptors on the primary cells involved called oligodendroglia. Recent studies have now confirmed what was suspected back then. The loss of myelin sheath on the nerve fibers characteristic of the disease are due to the death of these oligodendroglial cells at the site of the lesions (called plaques). Further, these studies have shown that the death of these important cells is as a result of excessive exposure to excitotoxins at the site of the lesions.
Normally, most of these excitotoxins are secreted from microglial immune cells in the central nervous system. This not only destroys these myelin-producing cells it also breaks down the blood-brain barrier (BBB), allowing excitotoxins in the blood stream to enter the site of damage. Aspartame contains the excitotoxin aspartate as 40% of its molecular structure. Numerous studies have shown that consuming aspartame can significantly elevate the excitotoxin level in the blood. There is a common situation during which the excitotoxin exposure is even greater. When aspartate (as aspartame) is combined in the diet with monosodium glutamate (MSG) blood levels are several fold higher than normal. With the BBB damaged, as in MS, these excitotoxins can freely enter the site of injury,greatly magnifying the damage. So, we see that dietary excitotoxins, such as aspartame and MSG, can greatly magnify the damage produced in multiple sclerosis. Likewise, excitotoxins have been shown to breakdown the BBB as well.
Of equal concern is observation that we know that about 10% of the population (based on autopsy studies of elderly) have MS lesions without ever developing the full blown disease, a condition called benign MS. A diet high in excitotoxins, such as aspartame, can convert this benign, subclinical condition into full-blown clinical MS. The amount of excitotoxins consumed in the average American diet is considerable, as shown by several studies. In addition, the toxin methanol is also in the aspartame molecule. Methanol is a axon poison. Combined toxicity of the aspartate and the methanol adds up to considerable brain toxicity and can convert benign, subclinical MS into full-blown MS. Once the MS becomes full-blown, further consumption of excitotoxins magnifies the toxicity, increasing disability and death.
Recent studies have also shown that even single exposures to these food-based excitotoxins can produce prolonged worsening of neurological lesions. In addition, it has been demonstrated that autoimmune reactions (as occurs with MS) greatly magnifies the toxicity of aspartate and glutamate (the excitotoxins). We also know liquid forms of excitotoxins are significantly more toxic because of rapid absorption and higher blood levels. In the face of this connection between excitotoxicity and the pathophysiology of MS, it would be ludicrous to allow further use of this excitotoxin containing sweetener..
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2. Yoshika A, et al. Pathophysiology of oligodendroglial excitotoxicity, J Neuroscience Research 46: 427-437, 1996.
3. Singh P, et al. Prolonged glutamate excitotoxicity: effects on mitochondrial antioxidants and antioxidant enzymes. Molecular Cell Biochemistry 243: 139-145, 2003.
4. Leuchtmann EA, et al. AMPA receptors are the major mediators of excitotoxin death in mature oligodendrocytes. Neurobiology of Disease 14:336-348, 2003.
5. Takahashi JL, et al. Interleukin1 beta promotes oligodendrocyte death through glutamate excitotoxicity. Annal Neurology 53: 588-595, 2003.
6. Pitt D, et al Glutamate uptake by oligodendrocytes: implications for excitotoxicity in multiple sclerosis. neurology 61: 1113-1120, 2003.
7. Soto A, et al. Excitotoxic insults to the optic nerve alter visual evoked potentials. Neuroscience 123: 441-449, 2004.
8. Blaylock RL. Interactions of cytokines, excitotoxins and reactive nitrogen and oxygen species in autism spectrum disorders. Journal of American Nutraceutical Association 6: 21-35, 2003.
9. Blaylock RL. Chronic microglial activation and excitotoxicity secondary to excessive immune stimulation: possible factors in Gulf War Syndrome and autism. Journal American Physicians and Surgeons, Summer, 2004.
TREATMENT FOR MS:
It is now known the cause for the destruction of the myelin in the lesions is overactivation of the microglia in the region of the myelin. An enzyme that converts glutamine to glutamate called glutaminase increases tremendously, thereby greatly increasing excitotoxicity. Mercury also activates microglia, even in subtoxic doses.
Any dietary excitotoxin can activate the microglia, thereby greatly aggravating the injury. This includes the aspartate in aspartame. The methanol adds to this toxicity as well. Now, the secret to treatment appears to be shutting down, or at least calming down, the microglia. It has been found that the antibiotic minocycline powerfully shuts down the microglia. I tried this treatment on a friend of mine who just came down with fulmanant MS. He was confined to a wheelchair. I had him placed on minocycline and now, just a few weeks later, he is walking.
The good news is that other things also calm the microglia-the most potent are: silymarin, curcumin and ibuprophen. Phosphatidylcholine helps re-myelinate the nerve sheaths that are damaged, as does B12, B6, B1, vitamin D, folate, vitamin C, natural vitamin E (mixed tocopherols) and L-carnitine. DHA plays a major role in repairing the myelin sheath. Vitamin D may even prevent MS, but it acts as an immune modulator, preventing further damage - the dose is 2000 IU a day. Magnesium, as magnesium malate, is needed in a dose of 500 mg 2X a day. They must avoid all excitotoxins, even natural ones in foods-such as soy, red meats, nuts, mushrooms and tomatoes. Avoid all fluoride and especially all vaccinations since these either inhibit antioxidant enzymes or triggers harmful immune reactions.
Dr. Blaylock is a recently retired board-certified neurosurgeon with more than twenty six years experience. He is a recently retired Clinical Assistant Professor of Neurosurgery at the Medical University of Mississippi. Author of thirty scientific papers on various medical subjects, chapters in three medical textbooks and a booklet on multiple sclerosis, he recently completed a booklet on bioterrorism and is the author of "Excitotoxins: The Taste That Kills", "Health & Nutrition Secrets to Save Your Life", and "Natural Strategies for Cancer Patients".
(http://www.russellblaylockmd.com/www.russellblaylockmd.com) He serves on the editorial staff of The Journal of American Physicians and Surgeons, the Journal of the American Nutraceutical Association, and acts as a medical advisor to the American Nutraceutical Association. His excellent newsletter can be gotten at http://www.blaylockreport.com/www.blaylockreport.com He lives in Ridgeland, Mississippi.
Note from Dr. Betty Martini :
Cori Brackett, co-owner of Sound and Fury Productions, an MS victim diagnosed at the Mayo Clinic, had a huge lesion in the brain. Cori was a user of the neurotoxic drug Aspartame, marketed as NutraSweet, Equal, Spoonful, E951, Canderel, Benevia, etc. Off the poison, she too walked out of her wheelchair; the lesion disappeared. Because of what she had endured from aspartame disease she felt a moral obligation to warn others, especially with 70% of the population and 40% of our children using this deadly toxin. Cori Brackett traveled 7000 miles and with 25 hours of footage produced the movie, "Sweet Misery: A Poisoned World." She says it reveals one of the most pervasive, insidious forms of corporate negligence in the history of the industrial revolution. On this date it is being released to the world. You will get to see the famed Dr. Blaylock and other aspartame experts, as well as hear the horror story of the victims. See Diane Fleming who is wilting in a Virginia prison because her athlete husband died of aspartame. She was sentenced to 50 years for the crime committed by the manufacturer who had the malice to market a poison. Don't miss this film. Contact Cori Brackett at Cori@soundandfuryproductions.com or 520-624-9710.
For years physicians have written the MS Society to alert them about aspartame. You can read my letter on http://www.dorway.com/nomarkle.html , never answered, of course. Faced with the choice of warning the public or continuing to receive funding from industry, the MS Society has chosen to sacrifice the victims. And when those responsible to solve the problem ARE the problem it is a sad commentary on greed and lack of concern for humanity. How can anyone set aside professional ethics to allow an MS holocaust, when simply alerting those with MS to avoid aspartame and other excitotoxins could save the lives of thousands. At one MS Society walk-a-thon, they were giving out free Diet Coke's while trying to prevent our activists from giving walkers info that could save the lives of MS victims. I simply turned to the crowd and said: "The MS Society does not want you to have this life-saving information on a product triggering this disease." The entire crowd took copies. Later I received several calls of those who had heeded the advice and gotten well. But I shudder to think how many have perished because the MS Society hasn't had the integrity to warn victims. Contact Information:
Dr. Betty Martini, Founder
Mission Possible Intl.
9270 River Club Parkway
Duluth, Georgia 30097
WORLD NATURAL HEALTH ORGANIZATION
See more aspartame lawsuits filed against companies knowingly
poisoning the public on www.wnho.net
Aspartame Toxicity Center: www.holisticmed.com/aspartame